Abstract | AIMS: DESIGN: Double-blind randomized placebo-controlled trial. PARTICIPANTS: Thirty cocaine-dependent injecting drug users. INTERVENTION: Subjects were assigned randomly to receive 60 mg/day dexamphetamine (n = 16) or placebo (n = 14) for 14 weeks. MEASUREMENTS: Immunoassay and mass spectrometric techniques were used to identify cocaine metabolites in urine. Subjects were screened using the Composite International Diagnostic Interview and DSM-IV. The Opiate Treatment Index, Brief Symptom Inventory, Severity of Dependence Scale and visual analogue craving scales were used to collect pre- and post-self-report data. FINDINGS: Treatment retention was equivalent between groups; however, outcomes favoured the treatment group with no improvements observed in the placebo control group. The proportion of cocaine-positive urine samples detected in the treatment group declined from 94% to 56% compared to no change in the placebo group (79% positive). While the improvements were not significant between groups, within-group analysis revealed that the treatment group reduced self-reported cocaine use (P = 0.02), reduced criminal activity (P = 0.04), reduced cravings (P < 0.01) and reduced severity of cocaine dependence (P < 0.01) with no within-group improvements found in the placebo group. CONCLUSIONS:
|
Authors | James Shearer, Alex Wodak, Ingrid van Beek, Richard P Mattick, John Lewis |
Journal | Addiction (Abingdon, England)
(Addiction)
Vol. 98
Issue 8
Pg. 1137-41
(Aug 2003)
ISSN: 0965-2140 [Print] England |
PMID | 12873248
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Central Nervous System Stimulants
- Cocaine
- Dextroamphetamine
|
Topics |
- Adult
- Central Nervous System Stimulants
(adverse effects, therapeutic use)
- Cocaine
(urine)
- Cocaine-Related Disorders
(rehabilitation, urine)
- Dextroamphetamine
(adverse effects, therapeutic use)
- Double-Blind Method
- Feasibility Studies
- Female
- Humans
- Male
- Patient Compliance
- Pilot Projects
- Treatment Outcome
|