Abstract | BACKGROUND AND OBJECTIVES: METHODS AND PARTICIPANTS: A population-based, cross-sectional sample of 410 adults from rural Spain was studied. The correlations between plasma leptin levels and left ventricular mass index, sum of wall thicknesses, and blood pressure were calculated. Multiple linear regression analysis was used to adjust for other cardiovascular risk factors. RESULTS: After adjusting for age, body mass index, systolic blood pressure, sex, and insulin resistance, leptin was inversely associated with left ventricular mass index (beta = -0.20, P < 0.01). Leptin was also inversely related to the sum of wall thicknesses; however, this association did not reach statistical significance (beta = -0.12, P = 0.063). Leptin was not statistically associated with blood pressure after adjusting for body mass index. CONCLUSIONS: The results do not support the hypothesis that leptin increases cardiovascular risk by increasing left ventricular mass index or blood pressure. Other mechanisms, related to atherosclerosis, could explain the increased risk of cardiovascular diseases observed with high leptin levels.
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Authors | Manel Pladevall, Keoki Williams, Heidi Guyer, Josep Sadurní, Carles Falces, Anna Ribes, Carles Paré, Carlos Brotons, Rafael Gabriel, Manuel Serrano-Ríos, Steven Haffner |
Journal | Journal of hypertension
(J Hypertens)
Vol. 21
Issue 8
Pg. 1467-73
(Aug 2003)
ISSN: 0263-6352 [Print] Netherlands |
PMID | 12872039
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Cross-Sectional Studies
- Female
- Humans
- Hypertension
(blood, epidemiology)
- Hypertrophy, Left Ventricular
(blood, epidemiology)
- Leptin
(blood)
- Linear Models
- Male
- Middle Aged
- Risk Factors
- Spain
(epidemiology)
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