Mithramycin in the treatment of systemic mastocytosis.

Abstract

A patient had systemic mastocytosis of 16 years' duration, with urticaria pigmentosa, osteopetrosis with severe bone pain, mastocytosis of the bone marrow with myeloid metaplasia, gastrointestinal malabsorption, and Cushingold features associated with prolonged usage of corticosteroids. Treatment with a single dose of mithramycin resulted in an abrupt disappearance of the patient's generalized bone pain, but it had little effect on his histamine release-type symptomatology.

• Authors: M E Conrad, J T Carpenter Jr, J N Todd 3rd, T M Murad
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 83 Issue 5 Pg. 659-60 (Nov 1975) ISSN: 0003-4819 [Print] United States
• PMID: 128307 (Publication Type: Case Reports, Journal Article)

Chemical References

• Plicamycin

Topics

• Adult
• Humans
• Male
• Osteopetrosis (drug therapy)
• Pain (drug therapy)
• Plicamycin (therapeutic use)
• Urticaria Pigmentosa (drug therapy)