Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSION: Persons with excess ascorbic acid supplement in the blood or plasma generate iron- chelator-suppressible chemiluminescents suggestive of free radical formation. Whether the findings occur in vivo or that the free radicals generated in vitro lead to toxicity in patients is not known from this study. These results suggest that either lower parenteral dose or lower infusion rate of ascorbic acid may be more appropriate for adjuvant therapy in iron-overloaded uremic patients.
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Authors | Wei-Teing Chen, Yuh-Feng Lin, Fu-Chiu Yu, Woei-Yau Kao, Wen-Hsin Huang, Horng-Chin Yan |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 42
Issue 1
Pg. 158-66
(Jul 2003)
ISSN: 1523-6838 [Electronic] United States |
PMID | 12830468
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Antioxidants
- Biphenyl Compounds
- Free Radical Scavengers
- Free Radicals
- Hydrazines
- Picrates
- Ferritins
- 1,1-diphenyl-2-picrylhydrazyl
- Iron
- Ascorbic Acid
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Topics |
- Aged
- Antioxidants
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Ascorbic Acid
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Biphenyl Compounds
(analysis)
- Female
- Ferritins
(blood)
- Free Radical Scavengers
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Free Radicals
(blood)
- Humans
- Hydrazines
(analysis)
- In Vitro Techniques
- Injections, Intravenous
- Iron
(blood, pharmacokinetics)
- Iron Overload
(blood, drug therapy, etiology)
- Kidney Failure, Chronic
(blood, therapy)
- Luminescent Measurements
- Male
- Middle Aged
- Oxidative Stress
- Picrates
- Renal Dialysis
(adverse effects)
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