Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis.

Abstract	Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.
Authors	John R Graybill, Rosie Bocanegra, Laura K Najvar, Steve Hernandez, Robert A Larsen
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 47 Issue 7 Pg. 2373-5 (Jul 2003) ISSN: 0066-4804 [Print] United States
PMID	12821503 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anti-Bacterial Agents Antifungal Agents Echinocandins Lipopeptides Peptides Peptides, Cyclic Fluconazole Caspofungin
Topics	Animals Anti-Bacterial Agents (pharmacology) Antifungal Agents (pharmacology) Candidiasis (drug therapy) Caspofungin Drug Therapy, Combination Echinocandins Fluconazole (pharmacology) Lipopeptides Mice Mice, Inbred BALB C Mice, Inbred ICR Peptides Peptides, Cyclic

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