Abstract |
Sterol regulatory element binding proteins (SREBPs) are membrane-bound transcription factors that control the metabolism of cholesterol and fatty acids in mammalian cells. We postulated that polymorphisms (SNPs) in SREBP-2 gene might influence lipid parameters and the risk of coronary atherosclerosis. PCR-SSCP analysis and direct sequencing of DNA from 64 asymptomatic hypercholesterolemic men revealed seven genetic SREBP-2 SNPs. The genotype distribution of four of these SNPs (1668G>T, 1784G>C, 3474T>C and 3705C>T), and their influence on plasma lipid values and clinical parameters was studied in 655 asymptomatic men previously selected for the presence of at least one cardiovascular risk factor ( hypertension, hypercholesterolemia, tobacco consumption). No significant relation was found with lipid parameters but there was a significant association between the 1784G>C polymorphism and intima-media thickness (IMT) measured in 497 subjects. Thus, a common variation in the SREBP-2 gene is related with early-stage carotid atherosclerosis in subjects with a risk of cardiovascular events without detectable change in plasma lipid levels.
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Authors | Peggy Robinet, Benoit Védie, Gilles Chironi, Jérôme Gariépy, Alain Simon, Nicole Moatti, Jean Louis Paul |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 168
Issue 2
Pg. 381-7
(Jun 2003)
ISSN: 0021-9150 [Print] Ireland |
PMID | 12801623
(Publication Type: Journal Article)
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Chemical References |
- DNA-Binding Proteins
- Lipids
- SREBF2 protein, human
- Sterol Regulatory Element Binding Protein 2
- Transcription Factors
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Topics |
- Adult
- Carotid Arteries
(diagnostic imaging)
- Carotid Artery Diseases
(genetics)
- DNA-Binding Proteins
(genetics)
- Femoral Artery
(diagnostic imaging)
- Gene Frequency
- Genotype
- Humans
- Hypercholesterolemia
(genetics)
- Hypertension
(genetics)
- Intracranial Arteriosclerosis
(genetics)
- Linkage Disequilibrium
- Lipids
(blood)
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Polymorphism, Single-Stranded Conformational
- Smoking
(genetics)
- Sterol Regulatory Element Binding Protein 2
- Transcription Factors
(genetics)
- Tunica Intima
(diagnostic imaging)
- Tunica Media
(diagnostic imaging)
- Ultrasonography
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