Abstract | BACKGROUND: METHODS: A total of 957 patients undergoing primary CABG were prospectively recruited into the Duke Cardiovascular database and had daily serum magnesium levels measured. Low magnesium was defined as <1.8 mmol/L(-1) at any point during the first 8 days after surgery. Adverse events were defined as Q-wave infarction or death measured 1 year after surgery. A Kaplan-Meier survival analysis was performed, followed by a Cox proportional hazards model, to account for other known predictors of adverse events. RESULTS: In the low magnesium group, 12.3% of patients had adverse events, compared with 9.2% of patients in the normal magnesium group. A serum magnesium level <1.8 mmol/L(-1) decreased the event-free survival rate (2-fold increased risk of death or myocardial infarction at 1 year; hazard ratio 2.0, 95% CI 1.19-3.37). CONCLUSIONS: We demonstrated a robust relationship between low serum magnesium levels after CABG and a 2-fold increased incidence of Q-wave infarction and all-cause mortality rate as long as 1 year after surgery. This relationship is independent of known preoperative and intraoperative predictors of adverse outcomes. This study provides a rationale for a randomized controlled trial of magnesium therapy during CABG.
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Authors | John V Booth, Barbara Phillips-Bute, Charles B McCants, Mihai V Podgoreanu, Peter K Smith, Joseph P Mathew, Mark F Newman |
Journal | American heart journal
(Am Heart J)
Vol. 145
Issue 6
Pg. 1108-13
(Jun 2003)
ISSN: 1097-6744 [Electronic] United States |
PMID | 12796771
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Aged
- Biomarkers
(blood)
- Cause of Death
- Coronary Artery Bypass
(mortality)
- Female
- Humans
- Magnesium
(blood)
- Male
- Middle Aged
- Myocardial Infarction
(blood, mortality)
- Predictive Value of Tests
- Proportional Hazards Models
- Prospective Studies
- Statistics, Nonparametric
- Time Factors
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