The relation of clinical symptoms and anti-ganglioside antibodies to MEPPs frequency increase in 8 cases of variant type Guillain-Barré syndrome.

Abstract

Many patients with variant forms of Guillain-Barré syndrome (vGBS) associated with anti-ganglioside antibodies, including Miller Fisher syndrome (MFS), sometimes exhibit miniature endplate potential (MEPP) frequency increases (MFI, described as alpha-latrotoxin-like effects in a previous report) and the factor to produce this effect is present in their sera. MFI-positive sera increase the frequency of MEPPs, then block neuromuscular transmission at the mouse neuromuscular junction. A connection between this effect at the neuromuscular junction and some vGBS symptoms is suspected. We measured MFI directly at several points during the clinical course of 8 vGBS patients who had various symptoms and courses. Six patients had confirmed MFI and this activity decreased with convalescence. In 3 clinically mild cases, we were able to elicit MFI using normal serum to supply complement after exposure to the patient's serum. The anti-GQ1b/GT1a IgG titer, the extent of ophthalmoplegia and the extent of MFI were significantly correlated. They did not correlate with the severity of limb weakness or the occurrence of respiratory failure. These results support the hypothesis that MFI caused by anti-ganglioside antibodies is the pathogenic mechanism responsible for ophthalmoplegia in vGBS; different mechanisms or antibodies may explain limb weakness and respiratory failure. Furthermore, MFI may be an important indicator of how serum injures the nerve terminals. The symptoms of vGBS may result from multiple pathogenic factors.

• Authors: Masahiko Kishi, Toshiki Fujioka, Hiroko Miura, Akiko Sekine, Hiroaki Iguchi, Hiroshi Nakazora, Tetuhito Kiyozuka, Osamu Igarashi, Yasumitu Ichikawa, Hideki Sugimoto, Teruyuki Kurihara, Sachiko Irie, Toyokazu Saito
• Journal: Journal of the peripheral nervous system : JPNS (J Peripher Nerv Syst) Vol. 8 Issue 2 Pg. 82-90 (Jun 2003) ISSN: 1085-9489 [Print] United States
• PMID: 12795712 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Anti-Idiotypic
• Calcium Channel Blockers
• Conotoxins
• Gangliosides

Topics

• Adult
• Aged
• Aged, 80 and over
• Animals
• Antibodies, Anti-Idiotypic (blood)
• Calcium Channel Blockers (pharmacology)
• Conotoxins (pharmacology)
• Cross Reactions
• Electric Stimulation
• Electrophysiology
• Enzyme-Linked Immunosorbent Assay
• Female
• Gangliosides (classification, immunology)
• Guillain-Barre Syndrome (blood, immunology, physiopathology)
• Humans
• Male
• Membrane Potentials (drug effects)
• Mice
• Mice, Inbred C57BL
• Middle Aged
• Motor Endplate (physiology)
• Muscles (physiology)
• Ophthalmoplegia (blood, physiopathology)
• Respiration Disorders (blood, physiopathology)
• Statistics as Topic (methods)
• Synaptic Transmission (drug effects, physiology)