Abstract | BACKGROUND AND PURPOSE: Breakdown of the blood-brain barrier during stroke allows central nervous system antigens to leak into the systemic circulation and allows circulating leukocytes access to the brain. Encounter of central nervous system antigens by the peripheral immune system can be capitalized on to modulate the postischemic inflammatory response and potentially improve outcome from stroke. METHODS: RESULTS: Median infarct volume in animals tolerized to MBP and those receiving splenocytes from MBP-tolerized donors was less than in animals tolerized to OVA and those receiving splenocytes from OVA-tolerized donors (87.7+/-54.9 versus 148+/-61.6 mm3 [P=0.01] and 89.2+/-77.5 versus 153+/-77.1 mm3 [P=0.05], respectively). There was an increase in the number of transforming growth factor-beta1-secreting mononuclear cells in MBP-tolerized animals undergoing sham surgery (P=0.001) as well as in ischemic animals 48 hours (P=0.02) and 336 hours (P=0.04) after stroke. A distinct subset of gammadelta T cells was present in the brains of MBP-tolerized but not control animals after stroke. CONCLUSIONS:
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Authors | Kyra Becker, Darin Kindrick, Richard McCarron, John Hallenbeck, Robert Winn |
Journal | Stroke
(Stroke)
Vol. 34
Issue 7
Pg. 1809-15
(Jul 2003)
ISSN: 1524-4628 [Electronic] United States |
PMID | 12791945
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Administration, Intranasal
- Adoptive Transfer
- Animals
- Brain Ischemia
(immunology, pathology, therapy)
- Cell Count
- Cerebral Infarction
(pathology, physiopathology, prevention & control)
- Cytoprotection
(immunology)
- Disease Progression
- Immune Tolerance
(immunology)
- Inflammation
(immunology, pathology)
- Lymphocytes
(immunology, physiology)
- Male
- Myelin Basic Protein
(administration & dosage, immunology)
- Nasal Mucosa
(immunology)
- Rats
- Rats, Inbred Lew
- Spleen
(cytology, immunology, transplantation)
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