Abstract | BACKGROUND:
Photodynamic therapy ( PDT) is a non-invasive method for topical and selective treatment of pre-malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia. METHODS: Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% delta-aminolevulinic acid (ALA) and light from an argon-pumped dye laser. Irradiation was performed in several (6-8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm2 per session. RESULTS: A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months. CONCLUSION:
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Authors | Aleksander Sieroń, Mariusz Adamek, Aleksandra Kawczyk-Krupka, Sebastian Mazur, Leszek Ilewicz |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 32
Issue 6
Pg. 330-6
(Jul 2003)
ISSN: 0904-2512 [Print] Denmark |
PMID | 12787039
(Publication Type: Journal Article)
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Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Administration, Topical
- Adult
- Aged
- Aminolevulinic Acid
(administration & dosage, therapeutic use)
- Humans
- Laser Therapy
- Leukoplakia, Oral
(drug therapy)
- Middle Aged
- Photochemotherapy
- Photosensitizing Agents
(administration & dosage, therapeutic use)
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