Evaluation of the antinociceptive effects of 4, alpha-dimethyl-m-tyramine (H 77/77) in the rat.

Abstract

4, alpha-Dimethyl-m-tyramine (H 77/77) has been shown to induce dose dependently antinociceptive activity against 3 parameters: (1) the motor (M), (2) the vocalisation during stimulation (V) and (3) the vocalisation after withdrawal of stimulation (VA) responses. The effect of H 77/77 upon the V and VA pain responses was abolished or reduced by prior treatment with phenoxybenzamine, chlorpromazine, H 44/68, FLA 63, reserpine and protriptyline, and was potentiated by atropine sulphate. It is suggested that H 77/77 may exert is inhibitory effect on painful stimulation predominantly by inhibiting spinal sensory input.

• Authors: G Paalzow, L Paalzow
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 36 Issue 2 Pg. 321-9 (Apr 1976) ISSN: 0014-2999 [Print] Netherlands
• PMID: 1278226 (Publication Type: Journal Article)

Chemical References

• Amines
• Analgesics
• Catecholamines
• Receptors, Drug
• Tyramine

Topics

• Amines (metabolism)
• Analgesics (pharmacology)
• Animals
• Brain (metabolism)
• Catecholamines (biosynthesis)
• Depression, Chemical
• Electric Stimulation
• Male
• Rats
• Receptors, Drug (drug effects)
• Time Factors
• Tyramine (analogs & derivatives, pharmacology)
• Vocalization, Animal (drug effects)