Idiopathic hypereosinophilic syndrome associated with cutaneous infarction and deep venous thrombosis.

Abstract

We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with cutaneous infarction and subsequent extensive deep vein thrombosis. The eosinophilia improved dramatically with systemic corticosteroid therapy. A variety of skin disorders have been associated with HES, although there are no previous reports of HES associated with cutaneous infarction. HES is a rare disorder characterized by a sustained overproduction of eosinophils and multisystem disease. The aetiology of the eosinophilia remains uncertain but clonal populations of abnormal T-cells producing interleukin 5 may be implicated.

• Authors: S Narayan, F Ezughah, G R Standen, J Pawade, C T C Kennedy
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 148 Issue 4 Pg. 817-20 (Apr 2003) ISSN: 0007-0963 [Print] England
• PMID: 12752146 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Prednisolone

Topics

• Adult
• Follow-Up Studies
• Glucocorticoids (therapeutic use)
• Humans
• Hypereosinophilic Syndrome (diagnosis, drug therapy)
• Infarction (diagnosis)
• Male
• Prednisolone (therapeutic use)
• Skin (blood supply)
• Venous Thrombosis (diagnosis)