Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease.

Abstract

OBJECTIVE:

Previous studies suggest that heat shock protein (HSP) 60 has a contributory role in atherosclerosis development. We examined whether circulating HSP70 protein and anti-HSP70 antibodies are associated with coronary artery disease (CAD).

METHODS AND RESULTS:

Blood samples from 421 patients (62% men, mean age 57 years) evaluated for CAD by coronary angiography were tested. Serum HSP70 was detectable in 67% of study subjects with levels ranging from 0.2 to 27.1 ng/mL (mean, 1.08; median, 0.5). HSP70 levels were higher in non-CAD patients than CAD patients (median, 0.72 versus 0.34; P=0.0006). Individuals with HSP70 levels above the median (0.5 ng/mL) had half the risk of CAD than individuals with levels below the median (adjusted odds ratio, 0.52; 95% confidence limit, 0.32 to 0.86). The association of high HSP70 levels with low CAD risk was independent of traditional CAD risk factors (P=0.011). Disease severity (number of diseased vessels) was also inversely associated with HSP70 protein levels (P=0.010). The adjusted odds ratio of having multivessel disease for patients with high HSP70 protein levels was 0.54 (95% confidence limit, 0.36 to 0.81). In contrast, no association between anti-HSP70 IgG seropositivity and the prevalence of CAD was found (P=0.916).

CONCLUSIONS:

These data provide the first evidence that high levels of human HSP70 are associated with the low CAD risk, probably through its multiple protective effects on a cell's response to stress.

• Authors: Jianhui Zhu, Arshed A Quyyumi, Hongsheng Wu, Gyorgy Csako, David Rott, Alexandra Zalles-Ganley, Jibike Ogunmakinwa, Julian Halcox, Stephen E Epstein
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 23 Issue 6 Pg. 1055-9 (Jun 01 2003) ISSN: 1524-4636 [Electronic] United States
• PMID: 12730089 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Heat-Shock Proteins
• Immunoglobulin G
• C-Reactive Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibody Specificity
• Autoantibodies (blood)
• C-Reactive Protein (analysis)
• Chest Pain (diagnostic imaging, etiology)
• Cohort Studies
• Coronary Angiography
• Coronary Disease (blood, epidemiology)
• Female
• Heat-Shock Proteins (blood, immunology, physiology)
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Prevalence
• Risk Factors
• Severity of Illness Index