[Evaluation of endothelial permeability in brain tumors by dynamic magnetic resonance tomography with magnevist contrast imaging on low-field MR-tomograph].

Abstract

In order to study the endothelial permeability to hydrophilic macromolecules in brain tumors we have developed a technique based on Gjedde-Rutland-Patlak approach to dynamic MRI study with Gd-DTPA injected intravenously, performed with low-field MRI tomograph Magnetom Open (Siemens medical). 27 patients with various brain tumors were referred for the study. The indices of Gd-DTPA transport to tumor tissue (KGd-DTPA) vary substantially, depending on the degree of malignancy and deliver essential information on microvascular permeability of tumor capillary bed.

• Authors: V Iu Usov, O B Velichko, O Iu Borodin, A B Garganeev, A A Shikunov, O N Boklag
• Journal: Vestnik rentgenologii i radiologii (Vestn Rentgenol Radiol) 2001 May-Jun Issue 3 Pg. 22-9 ISSN: 0042-4676 [Print] Russia (Federation)
• Vernacular Title: Otsenka endotelial'noĭ pronitsaemosti opukholeĭ mozga metodom dinamicheskoĭ magnitno-rezonansnoĭ tomografii s kontrastirovaniem Magnevistom na nizkopol'nom MR-tomografe..
• PMID: 12717930 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Adenoma (diagnosis)
• Astrocytoma (diagnosis)
• Brain Neoplasms (diagnosis)
• Capillary Permeability
• Central Nervous System Neoplasms (diagnosis)
• Contrast Media
• Ependymoma (diagnosis)
• Gadolinium DTPA
• Glioma (diagnosis)
• Humans
• Magnetic Resonance Imaging (instrumentation, methods)
• Meningeal Neoplasms (diagnosis)
• Meningioma (diagnosis)
• Pituitary Neoplasms (diagnosis)