Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: This intention-to-treat analysis, specified as a secondary objective in VA-HIT, determined using Cox proportional hazards models the 5-year combined incidence of nonfatal myocardial infarction, coronary heart disease (CHD) death, or stroke in relation to the presence or absence of insulin resistance (defined by the highest tertile of the homeostasis model assessment of insulin resistance, HOMA-IR) in conjunction with lower and higher levels of HDL cholesterol and triglycerides. The study population consisted of 2,283 men with known coronary heart disease (CHD), treated with either placebo or gemfibrozil, who could be subdivided into groups with diabetes with or without insulin resistance, with no diabetes but insulin resistance, and with neither diabetes nor insulin resistance. RESULTS: CONCLUSIONS:
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Authors | Sander J Robins, Hanna Bloomfield Rubins, Fred H Faas, Ernst J Schaefer, Marshall B Elam, James W Anderson, Dorothea Collins, Veterans Affairs HDL Intervention Trial (VA-HIT) |
Journal | Diabetes care
(Diabetes Care)
Vol. 26
Issue 5
Pg. 1513-7
(May 2003)
ISSN: 0149-5992 [Print] United States |
PMID | 12716814
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Cholesterol, HDL
- Hypolipidemic Agents
- Triglycerides
- Gemfibrozil
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Topics |
- Body Constitution
- Body Mass Index
- Cardiovascular Diseases
(epidemiology, mortality)
- Cholesterol, HDL
(blood)
- Diabetes Mellitus, Type 1
(blood)
- Diabetes Mellitus, Type 2
(blood)
- Diabetic Angiopathies
(epidemiology, mortality)
- Gemfibrozil
(therapeutic use)
- Humans
- Hypolipidemic Agents
(therapeutic use)
- Insulin Resistance
(physiology)
- Male
- Proportional Hazards Models
- Reference Values
- Risk Factors
- Survival Analysis
- Triglycerides
(blood)
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