Abstract | AIMS: This randomized, double-blind, placebo-controlled, parallel-group study evaluated the safety and efficacy of ezetimibe 10 mg/day in patients with primary hypercholesterolemia. METHODS AND RESULTS: Following dietary stabilization, a 2-12-week washout period, and a 4-week, single-blind, placebo lead-in period, 827 patients with baseline low-density lipoprotein cholesterol ( LDL-C) > or =3.36 mmol/l (130 mg/dl) to < or =6.47 mmol/l (250 mg/dl) and triglycerides < or =3.95 mmol/l (350 mg/dl) were randomized 3:1 to receive ezetimibe 10 mg or placebo orally once daily in the morning for 12 weeks. The primary efficacy endpoint was percentage reduction in direct plasma LDL-C. Ezetimibe reduced direct LDL-C by a mean of 17.7% from baseline to endpoint, compared with an increase of 0.8% with placebo (P<0.01). Response to ezetimibe was generally consistent across all subgroups analyzed. Ezetimibe also significantly improved levels of plasma total cholesterol, apolipoprotein B, high-density lipoprotein(2)-cholesterol and lipoprotein(a), and elicited a trend toward lower triglyceride levels. Ezetimibe did not alter the serum concentrations of lipid-soluble vitamins or significantly affect baseline or stimulated cortisol production. Ezetimibe was well tolerated, with a safety profile similar to that of placebo. CONCLUSIONS:
Ezetimibe, which significantly reduces LDL-C and favorably affects other lipid variables, may provide a well tolerated and effective new option for lipid management in the future.
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Authors | R H Knopp, H Gitter, T Truitt, H Bays, C V Manion, L J Lipka, A P LeBeaut, R Suresh, B Yang, E P Veltri, Ezetimibe Study Group |
Journal | European heart journal
(Eur Heart J)
Vol. 24
Issue 8
Pg. 729-41
(Apr 2003)
ISSN: 0195-668X [Print] England |
PMID | 12713767
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anticholesteremic Agents
- Azetidines
- Cholesterol, LDL
- Triglycerides
- Vitamins
- Cosyntropin
- Ezetimibe
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(therapeutic use)
- Azetidines
(therapeutic use)
- Cholesterol, LDL
(blood)
- Cosyntropin
(blood)
- Double-Blind Method
- Ezetimibe
- Female
- Humans
- Hypercholesterolemia
(blood, drug therapy)
- Male
- Middle Aged
- Single-Blind Method
- Triglycerides
(blood)
- Vitamins
(blood)
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