Prevention of progression of interstitial lung lesions by early combination therapy with corticosteroids and cyclosporine/cyclophosphamide in two patients with amyopathic dermatomyositis.

Abstract

Two patients with amyopathic dermatomyositis complicated by interstitial lung lesions were effectively treated with a combination of corticosteroids and cyclosporine and/or cyclophosphamide. A 48-year-old female patient was treated with pulse methylprednisolone and cyclosporine 2 months after onset of dermal symptoms. A 45-year-old male patient was treated with oral prednisolone and pulse cyclophosphamide 2 1/2 months after onset of dermal symptoms. Early evaluation of interstitial lung lesions and early extensive therapy may improve prognosis of interstitial lung lesions in patients with amyopathic dermatomyositis.

• Authors: Kota Sugisaki, Isao Takeda, Haruyo Iwadate, Takashi Kanno, Tomoe Nishimaki, Reiji Kasukawa
• Journal: Fukushima journal of medical science (Fukushima J Med Sci) Vol. 48 Issue 2 Pg. 103-10 (Dec 2002) ISSN: 0016-2590 [Print] Japan
• PMID: 12680614 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Cyclosporine
• Cyclophosphamide

Topics

• Adrenal Cortex Hormones (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Cyclosporine (administration & dosage)
• Dermatomyositis (complications, drug therapy)
• Disease Progression
• Drug Therapy, Combination
• Female
• Humans
• Lung Diseases, Interstitial (prevention & control)
• Male
• Middle Aged