Abstract | OBJECTIVES: METHODS: We examined the outcome of iodine-131 treatment in children and adolescents with Graves' disease, as related to dose. Three iodine-131 doses were compared: 72 to 108 Gy (80-120 microCi/g), 180 to 225 Gy (200-250 microCi/g), and 270 to 364 Gy (300-405 microCi/g) in 31 patients ranging in age from 7 to 18 years old. Thyroid status was assessed >1 year after therapy. RESULTS: We found that doses of 100 Gy (110 microCi/g), 200 Gy (220 microCi/g), and 300 Gy (330 microCi/g) resulted in hypothyroidism in 50%, 70%, and 95% of treated individuals, respectively. These data show that to insure ablation of thyroid tissue doses, >270 Gy (300 microCi/g) is needed, especially when the thyroid is large.
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Authors | Scott A Rivkees, Eugene A Cornelius |
Journal | Pediatrics
(Pediatrics)
Vol. 111
Issue 4 Pt 1
Pg. 745-9
(Apr 2003)
ISSN: 1098-4275 [Electronic] United States |
PMID | 12671107
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Child
- Dose-Response Relationship, Radiation
- Female
- Follow-Up Studies
- Graves Disease
(radiotherapy)
- Humans
- Hyperthyroidism
(radiotherapy)
- Hypothyroidism
(etiology)
- Iodine Radioisotopes
(administration & dosage, therapeutic use)
- Male
- Radiotherapy Dosage
- Thyroid Gland
(pathology, radiation effects)
- Treatment Outcome
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