Abstract |
Besides immunosuppression and UV radiation, human papillomavirus (HPV) infection was also suggested to be involved in the development of non- melanoma skin cancer, the most common malignancy after transplantation. In this study we used a comprehensive PCR assay to analyze the prevalence of individual HPV types in different skin lesions from transplant and non-transplant patients. HPV DNA was detected more frequently in squamous cell carcinomas (SCCs) of transplant recipients (75%) than the same lesion was in non-immunosuppressed patients (47%). Similar HPV prevalences were found in cutaneous warts (91% vs 94%), pre-malignant skin tumors (38% vs 36%), and normal skin specimens (17% vs 16%) of both patient populations. Overall, more than 40 different HPV types were identified. HPV types 5 and 8 were found more frequently in SCCs (26%) than in pre-cancerous (5%) or benign lesions (1%). All HPV 5- and HPV 8-positive SCCs were from immunosuppressed patients, indicating that infection with HPV 5 and HPV 8 may present an increased risk of SCC development in these patients.
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Authors | Thomas Meyer, Rüdiger Arndt, Ingo Nindl, Claas Ulrich, Enno Christophers, Eggert Stockfleth |
Journal | Transplant international : official journal of the European Society for Organ Transplantation
(Transpl Int)
Vol. 16
Issue 3
Pg. 146-53
(Mar 2003)
ISSN: 0934-0874 [Print] Switzerland |
PMID | 12664208
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA Primers
- Immunosuppressive Agents
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Topics |
- Base Sequence
- DNA Primers
- Humans
- Immunosuppression Therapy
(adverse effects)
- Immunosuppressive Agents
(adverse effects)
- Papillomaviridae
(genetics, isolation & purification)
- Papillomavirus Infections
(complications)
- Polymerase Chain Reaction
- Skin Neoplasms
(etiology, virology)
- Transplantation Immunology
- Tumor Virus Infections
(complications)
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