Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus.

Abstract

In patients with diarrhea caused by Vibrio parahaemolyticus, antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness. Tumor necrosis factor-alpha and lactoferrin levels were high during the acute stage in mucosal secretions and in plasma, whereas interleukin-1beta levels were high only in mucosal secretions. Duodenal and rectal biopsy specimens obtained at the onset of illness showed an acute inflammatory response. The lamina propria showed edema, congestion of blood vessels, and hemorrhage, with an increase in levels of polymorphonuclear neutrophils and macrophages. Strains belonging to different serotypes exhibited varying resistance to killing by serum; the O8:K21 strain was most sensitive. Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting.

• Authors: Firdausi Qadri, Muhammad Shamsul Alam, Mitsuaki Nishibuchi, Taufiqur Rahman, Nur Haque Alam, Jobayer Chisti, Seiichi Kondo, Junichi Sugiyama, Nurul Amin Bhuiyan, Minnie M Mathan, David A Sack, G Balakrish Nair
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 187 Issue 7 Pg. 1085-96 (Apr 01 2003) ISSN: 0022-1899 [Print] United States
• PMID: 12660923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Toxins
• Hemolysin Proteins
• Immunoglobulin A
• Lipopolysaccharides
• thermostable direct hemolysin
• C-Reactive Protein

Topics

• Adult
• Antibodies, Bacterial (immunology)
• Bacterial Toxins
• C-Reactive Protein (analysis)
• Child
• Feces (chemistry)
• Female
• Gastrointestinal Diseases (immunology, microbiology, pathology)
• Hemolysin Proteins (immunology)
• Humans
• Immunoglobulin A (immunology)
• Inflammation (immunology, microbiology, pathology)
• Intestines (immunology, microbiology, pathology)
• Leukocyte Count
• Lipopolysaccharides (immunology)
• Male
• Vibrio Infections (immunology, pathology)
• Vibrio parahaemolyticus (immunology)