Abstract | PURPOSE: To determine the prognostic importance of periintervention serum levels of acute-phase reactants in 6-month restenosis after stent implantation in the carotid artery. MATERIALS AND METHODS: One hundred eight consecutive patients with 70% or greater stenosis of the internal carotid artery (ICA) according to the North American Symptomatic Carotid Endarterectomy Trial criteria underwent successful stent implantation in the ICA in a prospective cohort study. Six-month patency was evaluated at color-coded duplex ultrasonography. The association between in- stent restenosis (> or =50%, North American Symptomatic Carotid Endarterectomy Trial criterion) and C-reactive protein (CRP) and serum amyloid A levels at baseline and at 24 and 48 hours after intervention was assessed. RESULTS: Restenosis was found in 15 (14%) patients within 6 months. CRP level at 48 hours, exemplary for the postintervention acute-phase response, was significantly (P =.01) associated with 6-month restenosis by using multiple logistic regression analysis. Recurrent stenosis after prior stent implantation in the carotid artery (odds ratio, 9.2; 95% CI: 1.6, 53.2; P =.01) and residual stenosis of 10%-30% after stent implantation (odds ratio, 9.7; 95% CI: 1.6, 59.3; P =.01) were independent clinical predictors of restenosis. CONCLUSION: Extent of vascular inflammatory response after stent implantation in the carotid artery measured with acute-phase reactants is associated with 6-month patency. Recurrent stenosis after prior stent implantation and initial suboptimal technical result seem to be clinically relevant predictors of postangioplasty outcome.
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Authors | Martin Schillinger, Markus Exner, Wolfgang Mlekusch, Helmut Rumpold, Ramazanali Ahmadi, Schila Sabeti, Wilfried Lang, Oswald Wagner, Erich Minar |
Journal | Radiology
(Radiology)
Vol. 227
Issue 2
Pg. 516-21
(May 2003)
ISSN: 0033-8419 [Print] United States |
PMID | 12649420
(Publication Type: Journal Article)
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Copyright | Copyright RSNA, 2003 |
Chemical References |
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Topics |
- Acute-Phase Proteins
(analysis)
- Acute-Phase Reaction
(blood)
- Aged
- Carotid Stenosis
(blood, surgery)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Prospective Studies
- Recurrence
- Stents
(adverse effects)
- Time Factors
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