Abstract | BACKGROUND: After exposure of neoplastic tissue to helium, a significant reduction of tumor growth has been detected in experimental studies, both in vitro and in vivo. This tumor-suppressive effect of helium is controversly discussed in the literature. It was therefore the aim of this study to investigate the influence of pneumoperitoneum with CO2, room air, or helium in a tumor-bearing small animal model comparing laparoscopic partial hepatic resection for hepatocellular carcinoma with conventional open partial hepatectomy. METHODS: RESULTS: Significant reduction of postoperative tumor recurrence and metastasis was observed in the group of animals receiving laparoscopic tumor resection under helium insufflation compared to open surgery or laparoscopic resection with air pneumoperitoneum. CONCLUSIONS:
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Authors | M Schmeding, P Schwalbach, S Reinshagen, F Autschbach, A Benner, C Kuntz |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 17
Issue 6
Pg. 951-9
(Jun 2003)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 12632132
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Carbon Dioxide
(adverse effects, therapeutic use)
- Carcinoma, Hepatocellular
(secondary, surgery)
- Disease Models, Animal
- Helium
(adverse effects, therapeutic use)
- Hepatectomy
(methods)
- Insufflation
(adverse effects, methods)
- Laparoscopy
(methods)
- Liver Neoplasms, Experimental
(surgery)
- Male
- Neoplasm Recurrence, Local
(etiology)
- Pneumoperitoneum, Artificial
(adverse effects, methods)
- Rats
- Rats, Inbred Strains
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