[Ossifying fibroma of the face and hyperparathyroidism in a chronic hemodialysis patient].

Abstract

The bony complications in secondary hyperparathyroidism in chronic renal failure are varied. The ossifying fibroma is a rare manifestation. We report a case of a 40 years old woman with indeterminate nephropathy undergoing hemodialysis since 1982. Since may 1995, the patient had a diffuse and intensive bone pain of the two inferior members inducing functional importance with apparition of endobuccal tumefaction in the hard palate with an important increase of the volume of the maxillo-mandibular complex six months later associated to disturbances of the deglutition and phonation. In december 1995, the serum parathyroid hormone level is measured at 1527.6 pg/ml and the serum alkaline phosphatase level at 1620 UI/l. The bony lesions are disseminated to all the skeleton in the form of a demineralization with an ossifying expansive process affecting the maxillo-mandibular complex. Calcemia was at 2.3 mmol/l and phosphoremia at 2.1 mmol/l. The surgical biopsy of this pseudotumor showed an aspect of ossifying fibroma. The cervical echography showed a left inferior parathyroid nodular. In june 1996, a subtotal parathyroidectomy was done. The 9th day after surgery, the serum parathyroid hormone level was at 103 pg/ml with normal calcemia and phosphoremia. Five years later, the volume of the tumor reduced moderately. This observation induces 3 commentaries: the bony manifestations associated to secondary hyperparathyroidism have sometimes a tumoral aspect, the ossifying fibroma may be for known as well as the brown tumor and the treatment of these tumors in complex justifying furthermore a rigorous prevention of the hyperparathyroidism in hemodialyzed patients.

• Authors: K Zahiri, R Rochdi, M G Benghanem, A Lemseffer, E Fatihi, K Hachim, B Ramdani, D Zaïd
• Journal: Nephrologie (Nephrologie) Vol. 24 Issue 1 Pg. 25-9 ( 2003) ISSN: 0250-4960 [Print] Switzerland
• Vernacular Title: Fibrome ossifiant de la face et hyperparathyroïdie chez une hémodialysée chronique.
• PMID: 12629903 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Alkaline Phosphatase
• Calcium

Topics

• Adult
• Alkaline Phosphatase (blood)
• Biopsy
• Calcium (blood)
• Female
• Fibroma, Ossifying (diagnosis, etiology)
• Humans
• Hyperparathyroidism (complications, surgery)
• Jaw Neoplasms (diagnosis, etiology)
• Kidney Failure, Chronic (therapy)
• Parathyroidectomy
• Renal Dialysis (adverse effects)