Abstract | BACKGROUND: METHODS: Seven hundred twenty-two patients with chronic glomerulonephritis (CGN) and 162 patients with diabetic nephropathy (DN) were stratified by protein intake: less than 0.50 g/kg/d (0.50-g/kg/d group), 0.51 to 0.65 g/kg/d (0.65-g/kg/d group), and 0.66 to 0.80 g/kg/d (0.80-g/kg/d group). To analyze the effect of combined AST-120 therapy (6 g/d) in patients on LPD therapy, the slope of the reciprocal of serum creatinine (1/Cr slope), which represents progression of CRF, was applied. RESULTS: (1) In patients with CGN, the addition of AST-120 with an LPD was as follows: the 1/Cr slope in the 0.50-g/kg/d (n = 152), 0.65-g/kg/d (n = 318), and 0.80-g/kg/d (n = 252) groups changed significantly from -430 x 10(-5) to -83 x 10(-5), -333 x 10(-5) to -102 x 10(-5), and -431 x 10(-5) to -116 x 10(-5) dL/mg/wk. (2) In patients with DN, the addition of AST-120 with an LPD was as follows: the 1/Cr slope in the 0.65-g/kg/d (n = 74) and 0.80-g/kg/d (n = 68) groups changed significantly from -602 x 10(-5) to -125 x 10(-5) and -646 x 10(-5) to -185 x 10(-5) dL/mg/wk. CONCLUSION: It is suggested that the addition of AST-120 to a mild LPD provides the comparable effect with a strict LPD in the point of suppressing the progress of CRF.
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Authors | Tsutomu Sanaka, Kumiko Fujimoto, Jun Niwayama, Hideki Nishimura, Takashi Naito, Chieko Higuchi, Tadao Akizawa, Keizo Koide, Shozo Koshikawa |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 41
Issue 3 Suppl 1
Pg. S35-7
(Mar 2003)
ISSN: 1523-6838 [Electronic] United States |
PMID | 12612949
(Publication Type: Journal Article)
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Chemical References |
- Oxides
- Carbon
- AST 120
- Creatinine
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Topics |
- Administration, Oral
- Adsorption
- Carbon
(administration & dosage)
- Chronic Disease
- Combined Modality Therapy
- Creatinine
(blood)
- Diabetic Nephropathies
(blood, complications, diet therapy, drug therapy)
- Diet, Protein-Restricted
(methods)
- Female
- Glomerulonephritis
(blood, complications, diet therapy, drug therapy)
- Humans
- Kidney Failure, Chronic
(blood, diet therapy, drug therapy, etiology)
- Male
- Microspheres
- Middle Aged
- Oxides
(administration & dosage)
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