[Autotransplantation of the spleen].

Abstract

Auto transplantation of the spleen can be performed in the patients with traumatic rupture of the spleen, in whom spleen could not be conserved in the other way. The right indication for this method is isolated rupture of the spleen (concvasation or complete devascularisation). This method is not recommended in the endangered patients, patients with previous disease of the spleen as well as in the patients with the perforation of the other abdominal organs at the same time. Auto transplantation was performed in 12 patients with isolated splenic rupture and hematoperitoneum, 11 men and one woman. The majority of patients are younger. In 8 patients, autotransplant was placed into big omentum, in three into lipomatous tissue surrounding left kidney, and in one into anterior abdominal wall. In all the patients from this group, following analysis were taken: MCV (middle volume of erythrocytes), HTC, Hb, Le, Glucose, urea, creatinin, sodium, potassium, alkali phosphatasis, target cells, Howell Jolly's bodies, Heinz's bodies, IgG, IgA, IgM, C3, C4, T3, T4, T8, B, segmentated, eosinophiles, lymphocytes, reticulocytes, thrombocytes, fibrinogen, PT, APTT, aggregation of thrombocytes and aggregation of thrombocytes on collagen. The same parameters were taken in 12 patients with surgery similar to splenectomy and in 12 after splenectomy. After splenectomy, there was decrease of the immunologic defending abilities of the organism because of the loss of the childrens function of the spleen, decreased level of the opsonines and tutsin, which leads to the impaired phagocytosis, decreased concentration of IgM and T and B lymphocytes, while in patients after auto transplantation the results were physiological. The most important thing in the assessment of the function of the autotransplanted spleen is scintigraphic investigation using 99mTc-denaturated red blood cells. In our study, auto transplant function was assessed in 10/12 patients by scintigraphy. Five years after surgery, no one patient was proved to have postsplenectomic sepsis.

• Authors: S Knezević, D Stefanović, M Petrović, Z Djordjević, S Matić, V Artiko, A Milovanović, M Popović
• Journal: Acta chirurgica Iugoslavica (Acta Chir Iugosl) Vol. 49 Issue 3 Pg. 101-6 ( 2002) ISSN: 0354-950X [Print] Serbia
• Vernacular Title: Autotransplantacija slezine.
• PMID: 12587457 (Publication Type: English Abstract, Journal Article)

Topics

• Female
• Follow-Up Studies
• Humans
• Male
• Spleen (injuries, transplantation)
• Splenectomy
• Splenic Rupture (surgery)
• Transplantation, Autologous (methods)
• Transplantation, Heterotopic (methods)