[Changes in plasma von Willebrand factor and nitric oxide levels in patients with pregnancy induced hypertension].

Abstract

OBJECTIVE:

To study the changes and clinical significance of plasma von Willebrand factor (vWF) and nitric oxide (NO) levels in patients with pregnancy induced hypertension (PIH).

METHODS:

Plasma vWF and NO were detected by ELISA and Griess assay respectively in 36 patients with PIH and 18 healthy pregnant women.

RESULTS:

The levels of plasma vWF in patients with moderate and severe PIH increased significantly. than those in healthy pregnancy. The levels of plasma NO in patients with PIH were significantly lower than those in healthy pregnancy. The higher the vWF levels or the lower the NO levels, the more severe in PIH. There was a negative correlation between the plasma vWF and NO levels.

CONCLUSION:

The results suggest that plasma vWF and NO concentration can be used as indicators in the judgement of the severity of PIH.

• Authors: L P Jin, C H Wang, J L Chen
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 26 Issue 5 Pg. 477-9 (Oct 28 2001) ISSN: 1000-5625 [Print] China
• PMID: 12536509 (Publication Type: English Abstract, Journal Article)

Chemical References

• von Willebrand Factor
• Nitric Oxide

Topics

• Adult
• Female
• Humans
• Nitric Oxide (blood)
• Pre-Eclampsia (blood)
• Pregnancy
• von Willebrand Factor (metabolism)