Abstract | OBJECTIVE: (1) To determine an alternative iron supplementation with better efficacy, compliance & safety in treatment of iron deficiency anemia during pregnancy, (2) to reduce blood transfusion during pregnancy, labor and puerperium. MATERIAL AND METHOD: A prospective comparative study. A total number of 60 pregnant women with the gestational age of 12-34 weeks were included in the study who were suffering from iron deficiency anemia. They were divided in 3 groups (A, B and C). Group A (n = 15) received intravenous iron sucrose according to recommended dose containing 500 mg of iron sucrose for storage, in group B (n = 20) iron sucrose was administered according to deficit calculated as per formula but 200 mg of iron was given for storage instead of 500 mg, to reduce cost. While group C received intra muscular iron Sorbitol in the dose used as practice. RESULTS: Mean hemoglobin in group A and B was 8.0 +/- 1.1 g/dl and 8.9 +/- 0.7 respectively, in group C, it was 8.8 +/- 0.9 g/dl. In group A & B initial hemoglobin was assessed 3 weeks post therapy which showed an average rise of 2.8 g/dl (group A) and 1.9 g/dl (group B) and second assessment of Hemoglobin was done prior to delivery (ave: 6.6 weeks) showed a total rise of 3.8 g/dl (group A) and 2.4 g/dl (group B). Pre delivery mean Hemoglobin in group A and B was 11.8 g/dl and 11.3 g/dl respectively. In group C, the Hemoglobin was assessed only prior to delivery (average: 8.4 weeks from the start of therapy), and a rise of 1.4 g/dl was observed with pre delivery mean Hemoglobin of 10.2 g/dl. Target hemoglobin levels i.e. 11 g/dl was achieved by 80% in Group A, 70% in Group B and 28% in Group C by the time of delivery. Blood transfusion was not required in any group. In group A and B one patient had moderate abdominal pain, 2 had weakness and shivering and 3 had phlebitis at the site where intravenous canula was retained. None of patient discontinued the therapy due to any adverse effect. In group C majority complained of pain at injection site while 5 patients dropped out from the study due to intolerance. CONCLUSION:
|
Authors | A Wali, A Mushtaq, Nilofer |
Journal | JPMA. The Journal of the Pakistan Medical Association
(J Pak Med Assoc)
Vol. 52
Issue 9
Pg. 392-5
(Sep 2002)
ISSN: 0030-9982 [Print] Pakistan |
PMID | 12532571
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Ferric Compounds
- Hemoglobins
- Ferric Oxide, Saccharated
- Glucaric Acid
|
Topics |
- Adult
- Anemia, Iron-Deficiency
(blood, drug therapy)
- Female
- Ferric Compounds
(administration & dosage, therapeutic use)
- Ferric Oxide, Saccharated
- Gestational Age
- Glucaric Acid
- Hemoglobins
(analysis, metabolism)
- Humans
- Injections, Intramuscular
- Injections, Intravenous
- Pregnancy
- Pregnancy Complications
(blood, drug therapy)
- Prospective Studies
- Treatment Outcome
|