RESULTS:
p57(kip2) protein positive-expression rate in
tumor tissues of
pancreatic cancer was 46.9 %, which was lower than that in adjacent pancreatic tissues (75.0 %) (chi(2)=5.317, P<0.05),
p57(kip2) protein positive-expression correlated significantly with
tumor cell differentiation (well-differentiation versus moderate or low-differentiation, P<0.05) but did not correlate significantly with
lymph node metastasis (
lymph node metastasis versus non-
lymph node metastasis, P>0.05); Rb gene
protein positive-expression rate in
tumor tissues was 50.0 %, which was also lower than that in adjacent pancreatic tissues (78.1 %) (chi(2)=5.497, P<0.05);
PCNA positive-expression rate was 71.9 %, being higher than that in adjacent pancreatic tissues (43.8 %) (chi(2)=5.189, P<0.05),
PCNA positive-expression also correlated significantly with
tumor cell differentiation and
lymph node metastasis (well-differentiation versus moderate or low- differentiation,
lymph node metastasis versus non-
lymph node metastasis, P<0.05).
Rb protein positive-expression rate in the
tumor tissues of
p57(kip2) protein positive-expression group was 53.3 %; and
Rb protein positive-expression rate in the
tumor tissues of
p57(kip2) protein negative-expression group was 47.1 %. There was no significant relationship between the two groups (r=0.16507, P>0.05).
CONCLUSION: