Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding.

Abstract	We used single photon emission computed tomography (SPECT) to study striatal [(123)I]beta-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [(123)I]beta-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.
Authors	Svenja Happe, Walter Pirker, Gerhard Klösch, Cornelia Sauter, Josef Zeitlhofer
Journal	Journal of neurology (J Neurol) Vol. 250 Issue 1 Pg. 83-6 (Jan 2003) ISSN: 0340-5354 [Print] Germany
PMID	12527997 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Radiopharmaceuticals 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane Cocaine
Topics	Aged Cocaine (analogs & derivatives) Corpus Striatum (diagnostic imaging, metabolism, pathology) Dopamine Plasma Membrane Transport Proteins Female Humans Male Membrane Glycoproteins Membrane Transport Proteins (metabolism) Middle Aged Nerve Tissue Proteins Nocturnal Myoclonus Syndrome (metabolism, physiopathology) Parkinson Disease (diagnostic imaging, metabolism, physiopathology) Polysomnography Radiopharmaceuticals Tomography, Emission-Computed, Single-Photon

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