[Benzylpenicillin efficacy for neutropenic infection prophylaxis in patients with cancer and postcytostatic neutropenia].

Abstract

Evaluation of benzylpenicillin (penicillin G) effect for infection prophylaxis at the oncological patients with severe postcytostatic neutropenia was performed. All the patients with neutrophils levels lower than 0.5 x 10(9)/L were recommended to use antibiotics for infection prophylaxis. Test-group (n = 40) used ciprofloxacin (0.5 g twice daily, per os) combined with benzylpenicillin (1.0 g four times daily, i/v); control group was treated by ciprofloxacin in the same dose only. Combination with benzylpenicillin resulted in statistically significant reduction of infections frequency among oncological patients.

• Authors: S V Minenko, N V Dmitrieva, K L Chimishkian, N V Zhukov, E N Sokolova, V B Larionova, V V Ptushkin
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 47 Issue 7 Pg. 13-9 ( 2002) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' naznacheniia benzilpenitsillina dlia profilaktiki neĭtropenicheskoĭ infektsii u bol'nykh s opukholevymi zabolevaniiami i posttsitostaticheskoĭ neĭtropenieĭ.
• PMID: 12516191 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Antineoplastic Agents
• Ciprofloxacin
• Penicillin G

Topics

• Adolescent
• Adult
• Anti-Infective Agents (therapeutic use)
• Antibiotic Prophylaxis
• Antineoplastic Agents (adverse effects)
• Bacterial Infections (etiology, prevention & control)
• Ciprofloxacin (therapeutic use)
• Enterococcus faecalis (drug effects)
• Female
• Humans
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Neoplasms (drug therapy)
• Neutropenia (chemically induced)
• Penicillin G (therapeutic use)