Altered insulin and glucagon secretion in treated genetic hyperlipemia: a mechanism of theraphy?

Abstract

The influence of Halofenate therapy on insulin and glucagon secretion was examined in the Zucker rat with genetic endogenous hyperlipemia. Coincident with the lipid lowering effects of Halofenate, the net change in the basal bihormonal axis favored glucagon, with the I/G molar ratio (Insulin/Glucagon) decreasing from 2.72 +/- 0.53 to 0.96 +/- 0.20 during treatment with this drug. Following arginine stimulation the I/G ratio remained reduced at 0.87 +/- 0.13 in Halofenate treated animals, contrasting with the statistically greater ratio of 2.5 +/- 0.55 in control animals. The Halofenate induced state of reduced insulin:glucagon was associated with hypolipemia, postarginine hyperglycemia, and hyperketonemia,-three metabolic parameters characteristic of glucagon excess relative to insulin. It is suggested that the lipid-lowering action of Halofenate in genetic hyperlipemia may reflect the altered bihormonal axis induced by the drug.

• Authors: R P Eaton, R Oase, D S Schade
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 25 Issue 3 Pg. 245-9 (Mar 1976) ISSN: 0026-0495 [Print] United States
• PMID: 1250161 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Glucose
• Glycolates
• Insulin
• Glucagon
• Arginine
• Halofenate

Topics

• Animals
• Arginine (pharmacology)
• Blood Glucose (metabolism)
• Disease Models, Animal
• Glucagon (blood)
• Glycolates (pharmacology)
• Halofenate (pharmacology, therapeutic use)
• Hyperglycemia (chemically induced)
• Hyperlipidemias (drug therapy, genetics, metabolism)
• Insulin (blood)
• Rats
• Rats, Inbred Strains