Abstract | BACKGROUND & OBJECTIVE: METHODS: MVD and VEGF were evaluated after immunohistochemical staining using antibody of vascular endothelium for factor VIII antigen and VEGF in 62 patients with node-negative breast carcinoma respectively. The patients were followed up. RESULTS:
VEGF and MVD were all associated with histological grade and relapse (P < 0.05), but no association with ER and tumorsize; the relapse-free survivals (RFS) and overall survivals of patients with high MVD or high VEGF expression were significantly lower than that of the patients with low MVD or low VEGF expression (P < 0.01). Moreover, the difference of survivals in the patients with high MVD and high VEGF expression were more obvious(P < 0.005). Meanwhile, there was association between MVD and VEGF (P < 0.01). CONCLUSIONS: The node-negative patients with high VEGF expression or high MVD would have poor prognosis. VEGF and MVD could be significant prognostic indicators for the patients with node-negative breast carcinoma. It has better prognostic value to connected VEGF and MVD. VEGF was an important factor in tumor angiogenesis.
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Authors | Hong-jiang Li, Jing Jing, Yang-bing Zhao, Jing-qiang Zhu, Shi-yu Zhang, Zong-dao Shi |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 21
Issue 1
Pg. 75-8
(Jan 2002)
China |
PMID | 12500403
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Endothelial Growth Factors
- Intercellular Signaling Peptides and Proteins
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Topics |
- Adult
- Breast Neoplasms
(blood supply, chemistry, pathology)
- Endothelial Growth Factors
(analysis)
- Female
- Humans
- Intercellular Signaling Peptides and Proteins
(analysis)
- Lymphatic Metastasis
- Lymphokines
(analysis)
- Middle Aged
- Neovascularization, Pathologic
(etiology)
- Prognosis
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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