Pharmacokinetics and biodistribution of genetically engineered antibodies.

Abstract

The engineering of monoclonal antibodies has created a new generation of pharmaceuticals with the desired pharmacokinetics and biodistribution properties. For radioimmunotherapy and radioscintigraphy, optimum tumor targeting can be achieved using engineered constructs that provide high antigen affinity and specificity, effective tumor penetration, circulation properties that allow high tumor uptake with acceptable doses to the normal tissues, and fast clearance allowing low background. Recent advances have made possible the development of antibodies with these properties.

• Authors: Surinder K Batra, Maneesh Jain, Uwe A Wittel, Subhash C Chauhan, David Colcher
• Journal: Current opinion in biotechnology (Curr Opin Biotechnol) Vol. 13 Issue 6 Pg. 603-8 (Dec 2002) ISSN: 0958-1669 [Print] England
• PMID: 12482521 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Antibodies
• Antibodies, Monoclonal
• Immunoglobulin Fragments

Topics

• Animals
• Antibodies (genetics, metabolism)
• Antibodies, Monoclonal (metabolism, pharmacokinetics)
• Cloning, Molecular (methods)
• Humans
• Immunoglobulin Fragments (biosynthesis, metabolism)
• Metabolic Clearance Rate
• Mice
• Neoplasms (metabolism)
• Protein Engineering (methods)
• Tissue Distribution