Abstract | PURPOSE: The risk of recurrence and progression of ductal carcinoma in situ ( DCIS) of the breast is best designated by morphological indicators, including the presence of necrosis. Our purpose was to identify molecular alterations underlying progression of DCIS. EXPERIMENTAL DESIGN: RESULTS: CONCLUSIONS: This study shows that although levels of gene expression are mostly similar between morphologically different DCIS, consistent differences in expression of a subset of genes can be identified between DCIS with and without necrosis.
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Authors | Adewale Adeyinka, Ethan Emberley, Yulian Niu, Linda Snell, Leigh C Murphy, Heidi Sowter, Charles C Wykoff, Adrian L Harris, Peter H Watson |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 8
Issue 12
Pg. 3788-95
(Dec 2002)
ISSN: 1078-0432 [Print] United States |
PMID | 12473591
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- AAMP protein, human
- Adaptor Proteins, Signal Transducing
- Biomarkers, Tumor
- Carrier Proteins
- Cell Cycle Proteins
- DNA Primers
- Neoplasm Proteins
- RNA, Neoplasm
- Receptors, Antigen, B-Cell
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Protein Kinases
- DBF2 protein, S cerevisiae
- Protein Serine-Threonine Kinases
- STK38 protein, human
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Topics |
- Adaptor Proteins, Signal Transducing
- Biomarkers, Tumor
(genetics, metabolism)
- Breast Neoplasms
(genetics, pathology)
- Carcinoma, Intraductal, Noninfiltrating
(genetics, pathology)
- Carrier Proteins
(genetics, metabolism)
- Cell Cycle Proteins
- Cell Hypoxia
(physiology)
- DNA Primers
(chemistry)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoenzyme Techniques
- Lasers
- Necrosis
- Neoplasm Proteins
(genetics, metabolism)
- Oligonucleotide Array Sequence Analysis
- Protein Kinases
(genetics, metabolism)
- Protein Serine-Threonine Kinases
- RNA, Neoplasm
(metabolism)
- Receptors, Antigen, B-Cell
(genetics, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Saccharomyces cerevisiae Proteins
- Transcription Factors
(genetics, metabolism)
- Tumor Cells, Cultured
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