Abstract | OBJECTIVE AND DESIGN:
Galectin-3 is a beta-galactoside- binding protein that plays a role in cell adhesion and tumour progression. It was shown recently to diagnose malignant follicular thyroid lesions accurately. The reliability of this marker in the differential diagnosis between medullary thyroid carcinoma and C-cell hyperplasia was studied by immunohistochemistry. PATIENTS: Tissue specimens were obtained from 34 patients belonging to families with medullary thyroid carcinoma who underwent prophylactic thyroidectomy for RET gene mutation and/or abnormally increased plasma calcitonin levels. RESULTS: CONCLUSIONS:
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Authors | Antongiulio Faggiano, Monique Talbot, Ludovic Lacroix, Jean Michel Bidart, Eric Baudin, Martin Schlumberger, Bernard Caillou |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 57
Issue 6
Pg. 813-9
(Dec 2002)
ISSN: 0300-0664 [Print] England |
PMID | 12460332
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Carcinoembryonic Antigen
- Galectin 3
- Calcitonin
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Topics |
- Adolescent
- Adult
- Biomarkers, Tumor
(analysis)
- Calcitonin
(analysis)
- Carcinoembryonic Antigen
(analysis)
- Carcinoma, Medullary
(chemistry, diagnosis)
- Chi-Square Distribution
- Child
- Child, Preschool
- Diagnosis, Differential
- Female
- Galectin 3
(analysis)
- Humans
- Hyperplasia
- Immunohistochemistry
(methods)
- Lymphatic Metastasis
- Male
- Precancerous Conditions
(diagnosis)
- Sensitivity and Specificity
- Thyroid Gland
(pathology)
- Thyroid Neoplasms
(chemistry, diagnosis)
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