[Variation of the thyrotropin-releasing-hormone (TRH) stimulated thyrotropin (TSH) response in comparison with the tyhroid-gland-suppression test and the triiodothyronine (T3) and thyroxine (T4) blood levels in the so-called euthyroid endocrine ophthalmopathy].

Abstract

21 patients with active signs of euthyroid Graves' disease were given 400 mug thyrotropin-releasing hormone (TRH) i.v. All subjects with unresponsiveness to TRH had a nonsuppressible thyroidal 131I-uptake. On the basis of serum total T3 14 patients were hyperthyroid, 2 more had an elevated value of free T3. 4 patients with normal total T3 and nonsuppressible 131I-uptake were unresponsive to TRH, in 2 of them the free T3 fraction was elevated, however. 4 subjects with nonsuppressible 131I-uptake had a TRH stimulated TSH response. 2 of these subjects had hyperthyroid values of free and total T3 in serum and responded to TRH with an exaggerate TSH increment. The variations of TRH responsiveness may demonstrate a different threshold of the pituitary and the peripheral T3 receptors.

• Authors: K W Wenzel
• Journal: Endokrinologie (Endokrinologie) Vol. 66 Issue 1 Pg. 67-73 (Sep 1975) ISSN: 0013-7251 [Print] Germany
• Vernacular Title: Variationen der Thyrotropin-Releasing-Hormone (TRH) stimulierten Thyreotropin (TSH)-Antwort im Vergleich zum Schilddrüsensuppressionstest und den Trijodthyronin (T3)-und Thyroxin (T4)-Serumspiegeln bei sogenannter euthyreoter endokriner Ophthalmopathie
• PMID: 1243821 (Publication Type: English Abstract, Journal Article)

Chemical References

• Iodine Radioisotopes
• Triiodothyronine
• Thyrotropin

Topics

• Graves Disease (blood)
• Humans
• Hyperthyroidism (blood)
• Iodine Radioisotopes (metabolism)
• Stimulation, Chemical
• Thyroid Gland (metabolism)
• Thyrotropin (administration & dosage, metabolism)
• Triiodothyronine (blood)