Using n-butyl cyanoacrylate and the fixed-catheter-tip technique in percutaneous implantation of a port-catheter system in patients undergoing repeated hepatic arterial chemotherapy.

Abstract

OBJECTIVE:

The purpose of our study was to evaluate the usefulness of adding n-butyl cyanoacrylate to microcoils to fix the catheter tip in percutaneous implantation of a port-catheter system for hepatic arterial-infusion chemotherapy.

SUBJECTS AND METHODS:

Ninety-three patients (64 men and 29 women; age range, 38-83 years; mean age, 62.2 years) with unresectable advanced liver cancer underwent percutaneous implantation of a port-catheter system with the catheter tip fixed at the gastroduodenal artery with microcoils and a mixture of n-butyl cyanoacrylate and iodized oil. The rates of successful implantation and complications closely associated with this technique and management of the complications were reviewed.

RESULTS:

Percutaneous port-catheter placement was successfully performed in all patients. However, in eight patients, complications occurred: hepatic arterial obstruction (n = 5, 5.4%); catheter dislocation (n = 2, 2.2%); recanalization of the gastroduodenal artery (n = 1, 1.1%); or movement of n-butyl cyanoacrylate (n = 1, 1.1%). In five of the eight patients with complications, hepatic arterial-infusion chemotherapy was continued either after observation of the patient to ensure that stability had been established or after treatment using comparatively easy interventional techniques. In three (3.2%) of the 93 patients, planned hepatic arterial-infusion chemotherapy could not be performed because of complications associated with the technique.

CONCLUSION:

Fixation of the catheter tip in the gastroduodenal artery using a combination of microcoils and a mixture of n-butyl cyanoacrylate and iodized oil is a useful and safe technique in percutaneous port-catheter placement for repeated hepatic arterial infusion chemotherapy.

• Authors: Takuji Yamagami, Shigeharu Iida, Takeharu Kato, Osamu Tanaka, Tatsuya Hirota, Toshiyuki Nakamura, Tsunehiko Nishimura
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 179 Issue 6 Pg. 1611-7 (Dec 2002) ISSN: 0361-803X [Print] United States
• PMID: 12438064 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Enbucrilate

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (administration & dosage)
• Catheters, Indwelling
• Enbucrilate (administration & dosage)
• Female
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial (methods)
• Liver Neoplasms (blood supply, drug therapy, secondary)
• Male
• Middle Aged
• Radiography, Interventional