Motor nerve conduction velocity after carbon monoxide or m-dinitrobenzene poisoning following elimination of the poisons.

Abstract

24 hrs after acute carbon monoxide or m-dinitrobenzene poisoning (about 60% CO-Hb or Met-Hb) the sciatic motor conduction velocity of rats is significantly reduced by 33% and 16% respectively. Whereas 48 hrs after methemoglobinemia the nerve conduction is normal, a retardation is detectable even 4 weeks following carboxyhemoglobinemia. Also, 4 weeks after single carbon monoxide intoxication producing a mean CO-Hb content of 19%, the motor conduction velocity is significantly decreased. This effect may be useful for detection of carbon monoxide intoxication after elimination of the poison. The results show that there are carbon monoxide effects independent of blockade of hemoglobin.

• Authors: D Pankow, W Glatzel, K Tietze, W Ponsold
• Journal: Archives of toxicology (Arch Toxicol) Vol. 34 Issue 4 Pg. 325-30 (Dec 18 1975) ISSN: 0340-5761 [Print] Germany
• PMID: 1243627 (Publication Type: Journal Article)

Chemical References

• Nitrobenzenes
• Carboxyhemoglobin

Topics

• Animals
• Carbon Monoxide Poisoning (physiopathology)
• Carboxyhemoglobin (analysis)
• Male
• Methemoglobinemia (chemically induced, physiopathology)
• Motor Neurons (drug effects, physiology)
• Neural Conduction (drug effects)
• Nitrobenzenes (poisoning)
• Rats
• Sciatic Nerve (physiopathology)
• Time Factors