Severe neutropenia due to naproxen therapy in rheumatoid arthritis: a case report and review of literature.

Abstract	Rheumatoid arthritis is a chronic inflammatory disease that primarily affects the joints and is often treated with non-steroidal anti-inflammatory drugs (NSAIDs) on demand and disease-modifying antirheumatic drugs (DMARDs), with a relatively low risk of side effects. Although an infrequent side effect, neutropenia has been described as a sequel of NSAIDs. We report a case of neutropenia proven (by rechallenge) to be due to naproxen therapy. The literature on neutropenia during treatment with NSAIDs and DMARDs is briefly reviewed.
Authors	R Kalksma, T L Th A Jansen, G A W Bruyn
Journal	The Netherlands journal of medicine (Neth J Med) Vol. 60 Issue 7 Pg. 289-91 (Aug 2002) ISSN: 0300-2977 [Print] Netherlands
PMID	12430576 (Publication Type: Case Reports, Journal Article, Review)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Naproxen
Topics	Anti-Inflammatory Agents, Non-Steroidal (adverse effects) Arthritis, Rheumatoid (drug therapy) Humans Male Middle Aged Naproxen (adverse effects) Neutropenia (chemically induced)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!