Abstract | BACKGROUND: METHODS: RESULTS: A marked increase in uPA-dependent plasminogen activation was detected in the CSF of patients with bacterial meningitis vs CSF of patients with GBS and controls. Accordingly, ELISA analysis of CSF revealed intrathecal upregulation of uPA protein in patients with bacterial meningitis. CSF concentrations of uPAR and PAI-1 were also elevated in these patients. The serum of patients with bacterial meningitis showed elevated protein levels of uPA, but not uPAR or PAI-1. Positive correlations were found between blood-CSF barrier breakdown and CSF uPA concentrations, and between CSF pleocytosis and CSF/serum ratios of the potent chemokine uPAR in patients with bacterial meningitis. Furthermore, an adverse clinical outcome in these patients correlated with serum uPA concentrations. CONCLUSION:
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Authors | Frank Winkler, Stefan Kastenbauer, Uwe Koedel, H Walter Pfister |
Journal | Neurology
(Neurology)
Vol. 59
Issue 9
Pg. 1350-5
(Nov 12 2002)
ISSN: 0028-3878 [Print] United States |
PMID | 12427882
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- PLAUR protein, human
- Plasminogen Activator Inhibitor 1
- Receptors, Cell Surface
- Receptors, Urokinase Plasminogen Activator
- Urokinase-Type Plasminogen Activator
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Topics |
- Adult
- Aged
- Blood-Brain Barrier
(physiology)
- Female
- Guillain-Barre Syndrome
(blood, cerebrospinal fluid)
- Haemophilus Infections
(blood, cerebrospinal fluid)
- Haemophilus influenzae
- Humans
- Leukocyte Count
- Male
- Meningitis, Bacterial
(blood, cerebrospinal fluid)
- Middle Aged
- Plasminogen Activator Inhibitor 1
(blood, cerebrospinal fluid)
- Receptors, Cell Surface
(blood)
- Receptors, Urokinase Plasminogen Activator
- Staphylococcal Infections
(blood, cerebrospinal fluid)
- Staphylococcus aureus
- Streptococcal Infections
(blood, cerebrospinal fluid)
- Streptococcus pneumoniae
- Urokinase-Type Plasminogen Activator
(blood, cerebrospinal fluid)
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