Plasma antioxidant activity and vascular dementia.

Abstract	Little is known about the role of antioxidant activity in the pathogenesis of stroke-associated neuronal damage and impairment following a stroke. Increased free radical formation together with reduced antioxidant defense may increase neuronal injury. A low concentration of antioxidants such as alpha-tocopherol may influence the development of post-stroke dementia. The aim of this study was to evaluate the level of alpha-tocopherol and susceptibility of LDL to oxidation in a group of patients with dementia in comparison to controls. In a group of 68 patients with dementia, according to DSM-IV criteria, 42 with vascular dementia (VaD), 26 with Alzheimer type of dementia (AD) and 46 age-matched persons, with no signs of cognitive disorders (control group), we measured lipids, alpha-tocopherol and the kinetics of LDL oxidation. The levels of triglycerides (TG) and low-density lipoprotein (LDL) were significantly lower in patients with VaD in comparison to AD patients, but the atherogenic index was similar in both groups. alpha-Tocopherol was significantly lower in patients with VaD in comparison to patients with AD and controls: 9.9, 12.6 and 12.6 ng/ml, respectively, p<0.0001. Susceptibility of LDL to oxidation, measured by duration of lag phase did not reveal statistically significant differences between the groups. In patients with VaD, low levels of plasma alpha-tocopherol were observed, which indicate a reduced antioxidant defense in these subjects.
Authors	Danuta Ryglewicz, Maria Rodo, Piotr Krzysztof Kunicki, Malgorzata Bednarska-Makaruk, Alla Graban, Wanda Lojkowska, Hanna Wehr
Journal	Journal of the neurological sciences (J Neurol Sci) Vol. 203-204 Pg. 195-7 (Nov 15 2002) ISSN: 0022-510X [Print] Netherlands
PMID	12417383 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antioxidants Vitamin E Cholesterol
Topics	Aged Alzheimer Disease (blood, psychology) Antioxidants (metabolism) Cholesterol (blood) Chromatography, High Pressure Liquid Dementia, Vascular (blood, psychology) Female Humans Male Neuropsychological Tests Psychiatric Status Rating Scales Vitamin E (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!