Abstract |
Narcotic dependence in rats was established, in five days, by administering intravenous injections of morphine sulfate in increasing doses. From day six onward, dependence was maintained by administering a morphine injection (15 mg/kg) every 6 h throughout the day, and each of these injections was paired with a tone. After 16 morphine-tone pairings, test trials, in which the tone was presented in the absence of morphine, were instituted. These tone presentations significantly reduced morphine-withdrawal "wet shakes" in rats which received morphine-tone pairings, but not in rats which received control treatments.
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Authors | R Numan, N Smith, H Lal |
Journal | Psychopharmacology communications
(Psychopharmacol Commun)
Vol. 1
Issue 3
Pg. 295-303
( 1975)
ISSN: 0098-616X [Print] United States |
PMID | 1241454
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Topics |
- Acoustic Stimulation
- Animals
- Behavior, Animal
- Conditioning, Operant
- Humans
- Male
- Morphine Dependence
(physiopathology)
- Rats
- Substance Withdrawal Syndrome
(physiopathology)
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