From the screening of a number of new
pyrazole derivatives, the title compound,
PZ-177, was selected as the most significant derivative for analgestic and anti-edematous actions, in this paper, we report the anti-edematous activity of
PZ-177 as assessed by detailed analysis.
PZ-177 showed a markedly inhibitory effect against rat paw
edema induced by various phlogists (carragenin,
dextran, egg
albumin,
serotonin,
formalin and
bradykinin). It also inhibited
edema induced by anti-rat rabbit serum. The activity of
PZ-177 was more potent than that of
mepirizole and the same as that of
phenylbutazone. Though this agent has a central depressive effect, it is considered that the action has actually little influence on anti-edematous effect, as
carrageenin-induced
edema was inhibited in spinal rats. On the other hand, the anti-edematous effect of
PZ-177 was reduced significantly in adrenalectomized rats. It is therefore suggested that the potent anti-edematous action of
PZ-177 is exerted partially by a direct action at the inflamed site and mediated partially by stimulation of the hypophysis-adrenal system.