Abstract | OBJECTIVES: MATERIALS AND METHODS: Seven controls and three patients underwent MR and PET scanning. Coregistered static scans 40 minutes postinjection of [ 11C]PK11195 were used for assessment of relative ligand uptake by comparison to whole-brain uptake. RESULTS: For static scans acquired in near steady-state, the relative ligand uptake was significantly higher in gray matter structures as compared to the whole brain (ratio: 1.041 +/- 0.06, p = 0.036) whereas it was comparable in white matter (1.010 +/- 0.035). Intersubject reproducibility was 11.4% and 12.9% for white and grey matter. Intrasubject reproducibility was of the same order: 14.0% and 14.5% respectively. In two clinically active patients with Gadolinium-positive T1-weighted lesions on MRI the focal ligand uptake was significantly increased (1.36 and 1.14, p = 0.001). In one clinically stable patient, the uptake value corresponding with a T2-weighted MR lesion was not different from normal brain measurements. CONCLUSION: The current investigations show that normal brain uptake of [ 11C]PK11195 is very low and shows the feasibility of a semiquantitative method which can be applied to larger cohorts of patients subgroups.
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Authors | Jan C Debruyne, Koen J Van Laere, Jan Versijpt, Filip De Vos, Johan Keppens Eng, Karel Strijckmans, Patrick Santens, Eric Achten, Guido Slegers, Jacob Korf, Rudi A Dierckx, Jacques L De Reuck |
Journal | Acta neurologica Belgica
(Acta Neurol Belg)
Vol. 102
Issue 3
Pg. 127-35
(Sep 2002)
ISSN: 0300-9009 [Print] Italy |
PMID | 12400251
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoquinolines
- Ligands
- Benzodiazepines
- PK 11195
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Topics |
- Adult
- Benzodiazepines
- Brain
(diagnostic imaging)
- Female
- Humans
- Isoquinolines
(pharmacokinetics)
- Ligands
- Magnetic Resonance Imaging
- Male
- Multiple Sclerosis
(diagnostic imaging, metabolism)
- Radiography
- Reproducibility of Results
- Tomography, Emission-Computed
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