Abstract | AIM: Comparison of two treatment regimens of eradication treatment of duodenal ulcer (DU) associated with Helicobacter pylori based on fromilid ( clarithromycin). MATERIAL AND METHODS: 20 DU patients associated with HP were divided into two groups. 10 patients of group 1 received omeprazol, fromilid and metronidazol and 10 patients of group 2 were given omeprazol, fromilid and furasolidon for 7 days followed by 2-week omeprazol alone. The patients were examined clinically and endoscopically; HP were detected with a fast urease test and polymerase chain reaction before and after the treatment. Control examinations were performed 6 weeks after the medication. RESULTS: In group 1 duodenal healing was observed in all the 10 patients, HP eradication occurred in 9 of 10 patients by urease test and in 4 patients by PCR, in group 2 in 8 of 10, 10 of 10 and 10 of 10, respectively. CONCLUSION: Fromilid ( clarithromycin) is effective in eradication treatment in combination with fromilid and metronidazol or furazolidon.
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Authors | Iu V Vasil'ev, L A Zvenigorodskaia, E V Kolomiets, V Iu Firsanova |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 74
Issue 8
Pg. 58-60
( 2002)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Fromilid (klaritromitsin) v éradikatsionnoĭ terapii bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki, assotsiirovannoĭ s Helicobacter pylori (rezul'taty sopostavleniia dvukh variantov lecheniia). |
PMID | 12360599
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Metronidazole
- Clarithromycin
- Omeprazole
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Topics |
- Adolescent
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Clarithromycin
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Duodenal Ulcer
(drug therapy, microbiology)
- Female
- Helicobacter Infections
(drug therapy, microbiology)
- Helicobacter pylori
(genetics, isolation & purification)
- Humans
- Male
- Metronidazole
(administration & dosage, therapeutic use)
- Middle Aged
- Omeprazole
(administration & dosage, therapeutic use)
- Polymerase Chain Reaction
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