Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

Abstract	Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen. In a systemic infection, CD11c(lo) DC, but not neutrophils, provide critical survival signals, which can be inhibited by TACI-Fc, to antigen-specific MZ B cells and promote their differentiation into IgM-secreting plasmablasts. In a local TI response, peritoneal cavity macrophages provide similar support to B1 B-derived Ag-specific blasts. In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses.
Authors	Mercedesz Balázs, Flavius Martin, Tong Zhou, John Kearney
Journal	Immunity (Immunity) Vol. 17 Issue 3 Pg. 341-52 (Sep 2002) ISSN: 1074-7613 [Print] United States
PMID	12354386 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antigens, T-Independent CD11c Antigen Immunoglobulin M Membrane Proteins Receptors, Tumor Necrosis Factor Tnfrsf13b protein, mouse Transmembrane Activator and CAML Interactor Protein
Topics	Adoptive Transfer Animals Antigen Presentation (immunology) Antigens, T-Independent (immunology) Apoptosis (immunology) B-Lymphocyte Subsets (immunology) Bacteria (immunology) Blood Cells (immunology) CD11c Antigen (analysis) Cell Differentiation Cells, Cultured (immunology) Chemotaxis, Leukocyte Dendritic Cells (immunology) Immunoglobulin M (biosynthesis, immunology) Immunologic Deficiency Syndromes (immunology) Lymphocyte Activation (immunology) Macrophages, Peritoneal (immunology) Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neutrophils (immunology) Plasma Cells (immunology) Receptors, Tumor Necrosis Factor (immunology) Spleen (cytology, immunology) Transmembrane Activator and CAML Interactor Protein

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