Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity.

Abstract	We examined serotonin (5-HT) transporters in rat forebrain using quantitative autoradiography at three distinct developmental stages after neonatal 6-hydroxydopamine lesions. The lesions substantially increased 5-HT transporter binding in both caudate-putamen and nucleus accumbens, but not cerebral cortex. The effects reached maximal levels as early as postnatal day (PD) 24, and were sustained until early adulthood. Behavioral analyses indicated that neonatal lesions resulted in motor hyperactivity on PD 24, but not on PD 36 or 59. These findings suggest that excess 5-HT transporters reflect serotonin hyperinnervation reported to occur in lesioned rats, and may modulate motor hyperactivity.
Authors	Kehong Zhang, Eugen Davids, Frank I Tarazi, Ross J Baldessarini
Journal	Brain research. Developmental brain research (Brain Res Dev Brain Res) Vol. 137 Issue 2 Pg. 135-8 (Aug 30 2002) ISSN: 0165-3806 [Print] Netherlands
PMID	12220705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Carrier Proteins Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Serotonin Plasma Membrane Transport Proteins Slc6a4 protein, rat Serotonin Oxidopamine
Topics	Aging (metabolism) Animals Animals, Newborn Attention Deficit Disorder with Hyperactivity (metabolism, physiopathology) Carrier Proteins (metabolism) Disease Models, Animal Female Hyperkinesis (chemically induced, metabolism, physiopathology) Male Membrane Glycoproteins (metabolism) Membrane Transport Proteins Neostriatum (growth & development, metabolism, physiopathology) Nerve Tissue Proteins Neuronal Plasticity (physiology) Nucleus Accumbens (growth & development, metabolism, physiopathology) Oxidopamine Presynaptic Terminals (metabolism) Rats Rats, Sprague-Dawley Serotonin (metabolism) Serotonin Plasma Membrane Transport Proteins Synaptic Transmission (physiology) Up-Regulation (physiology)

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