Tardive dystonia and genetic polymorphisms of cytochrome P4502D6 and dopamine D2 and D3 receptors: a preliminary finding.

Abstract

Tardive dystonia is an uncommon but intractable and distressing complication of neuroleptic treatment. It is suggested that individual predisposing vulnerability plays a major role in the development of the side effect. This study aimed to investigate relationship tardive dystonia and several genetic factors such as polymorphism of cytochrome P4502D6, and receptor polymorphisms of dopamine D(2) (TaqI A and -141C Ins/Del polymorphisms) and D(3) (Ser(9)Gly polymorphism). Nine patients with tardive dystonia were genotyped for these genetic polymorphisms. No specific genotypes or alleles were overpresented in the patients. This study suggests that these polymorphisms are not related to the development of tardive dystonia.

• Authors: Kazuo Mihara, Tsuyoshi Kondo, Hisashi Higuchi, Hitoshi Takahashi, Keizo Yoshida, Tetsuo Shimizu, Sunao Kaneko
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 114 Issue 6 Pg. 693-5 (Aug 08 2002) ISSN: 0148-7299 [Print] United States
• PMID: 12210290 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Wiley-Liss, Inc.

Chemical References

• Antipsychotic Agents
• DRD3 protein, human
• Receptors, Dopamine D2
• Receptors, Dopamine D3
• Cytochrome P-450 CYP2D6

Topics

• Adult
• Alleles
• Antipsychotic Agents (therapeutic use)
• Cytochrome P-450 CYP2D6 (genetics)
• Dystonia (genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic
• Receptors, Dopamine D2 (genetics)
• Receptors, Dopamine D3
• Schizophrenia (genetics, therapy)