Infections of chickens with Escherichia coli serotype O78 can be treated with the
antibiotic sarafloxacin. Three experiments were conducted on the administration of this
drug to chickens that had been experimentally infected with E. coli. The birds were monitored for 10 days after
infection for their average daily gain (ADG) and feed conversion ratio (FCR), and the post-mortem pathology was assessed. In the first experiment,
sarafloxacin (20 mg/L, equivalent to 5 mg/kg live weight per day), given in the
drinking water for 3 days after
infection, led to a reduction in the mortality from 75% to 27%, but the ADG of the treated birds was still less than that of the uninfected controls. In the second experiment, when the
sarafloxacin was administered at the same dose in the water but over only 2 h, there was also a considerable reduction in mortality, and the ADG and the FCR also improved significantly. In the third experiment, the dose dependence of the
drug was tested. The birds were given 5 and 10 mg/kg per day
sarafloxacin in each group, starting within 2 h after
infection. This rapid administration of the
drug completely prevented mortality, while the ADG and FCR were similar to those of the uninfected controls.