Abstract | BACKGROUND: OBJECTIVES: Our aim is to investigate if the enhanced recovery is due to an anti-oxidant property of almitrine, since the electron transport chain is a major site of intracellular free radical production. METHODS: RESULTS:
Almitrine (6 and 10 microg/ml) given before fatigue gave better recovery rates than postfatigue application. In contrast, NAC (100 microM) application before fatigue onset was not as effective as NAC given immediately after the cessation of the fatigue protocol. However, almitrine (6 microg/ml) completely reversed the reduction in baseline twitch tension brought about by a free-radical-producing mixture of FeCl(3) + ADP (1 mM + 2.5 mM, respectively). CONCLUSION:
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Authors | F Markos, D P Campion, M Carey, J J O'Connor |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 69
Issue 4
Pg. 339-43
( 2002)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 12169748
(Publication Type: Journal Article)
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Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Respiratory System Agents
- Almitrine
|
Topics |
- Almitrine
(pharmacology)
- Animals
- Diaphragm
- In Vitro Techniques
- Male
- Muscle Fatigue
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Respiratory Muscles
(drug effects, physiology)
- Respiratory System Agents
(pharmacology)
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